Randomized controlled trialHumanClinical Trial, Phase III

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment

The New England journal of medicine, 2025 Nov 6. Wharton S, Aronne LJ, Stefanski A and 11 others.

Study type
Randomized controlled trial · Clinical Trial, Phase III
Subjects
Human participants (PubMed MeSH: Humans)
Journal
The New England journal of medicine
Published
2025 Nov 6
PubMed
PMID 40960239 ↗
DOI
10.1056/NEJMoa2511774 ↗

Where PepCue cites this

This paper is part of the evidence base behind this profile. Citing a study is not an endorsement of the compound: papers that found no effect are indexed the same way.

Orforglipron →

Indexed under

MeSH terms assigned by the National Library of Medicine.

AdultFemaleHumansMaleMiddle AgedAdministration, OralAnti-Obesity AgentsDouble-Blind MethodGlucagon-Like Peptide-1 Receptor AgonistsIntention to Treat AnalysisObesityWeight Loss

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Randomized controlled trial · 2026
Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial
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Orforglipron Added to Titrated Insulin Glargine in Type 2 Diabetes: The ACHIEVE-5 Randomized Clinical Trial
Randomized controlled trial · 2025
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes
Randomized controlled trial · 2023
Daily Oral GLP-1 Receptor Agonist Orforglipron for Adults with Obesity
Randomized controlled trial · 2023
Efficacy and safety of oral orforglipron in patients with type 2 diabetes: a multicentre, randomised, dose-response, phase 2 study

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Compounds