Randomized controlled trialHumanClinical Trial, Phase III

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes

The New England journal of medicine, 2025 Sep 18. Rosenstock J, Hsia S, Nevarez Ruiz L and 10 others.

Study type
Randomized controlled trial · Clinical Trial, Phase III
Subjects
Human participants (PubMed MeSH: Humans)
Journal
The New England journal of medicine
Published
2025 Sep 18
PubMed
PMID 40544435 ↗
DOI
10.1056/NEJMoa2505669 ↗

Where PepCue cites this

This paper is part of the evidence base behind this profile. Citing a study is not an endorsement of the compound: papers that found no effect are indexed the same way.

Orforglipron →

Indexed under

MeSH terms assigned by the National Library of Medicine.

AdultAgedFemaleHumansMaleMiddle AgedAdministration, OralDiabetes Mellitus, Type 2Dose-Response Relationship, DrugDouble-Blind MethodGlucagon-Like Peptide-1 Receptor AgonistsGlycated Hemoglobin

Other papers on Orforglipron

Randomized controlled trial · 2026
Efficacy and safety of once-daily oral orforglipron compared with oral semaglutide in adults with type 2 diabetes (ACHIEVE-3): a multinational, multicentre, non-inferiority, open-label, randomised, phase 3 trial
Randomized controlled trial · 2026
Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial
Randomized controlled trial · 2026
Orforglipron Added to Titrated Insulin Glargine in Type 2 Diabetes: The ACHIEVE-5 Randomized Clinical Trial
Randomized controlled trial · 2025
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment
Randomized controlled trial · 2023
Daily Oral GLP-1 Receptor Agonist Orforglipron for Adults with Obesity
Randomized controlled trial · 2023
Efficacy and safety of oral orforglipron in patients with type 2 diabetes: a multicentre, randomised, dose-response, phase 2 study

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Compounds