Cognitive neuropeptides

Peptides studied for effects on cognition, mood, and the nervous system.

How this class works

Proposed neuromodulatory and neurotrophic mechanisms. Human evidence varies and is often limited; nootropic claims frequently outrun the data.

Best-supported in this class

Semax grades highest (D-tier) on current published evidence. This reflects evidence maturity — not a recommendation to use anything.

Compounds in this class

SemaxD
Early human
Best for: early cognitive / focus research
In progress
SelankD
Early human
Best for: early cognitive / focus research
In progress
N Acetyl Semax AmidateF
Mechanism
Best for: early cognitive / focus research
In progress
DsipF
Anecdote
Best for: early sleep research
In progress
DihexaF
Mechanism
Best for: early cognitive / focus research
In progress

Head-to-head: Semax vs Selank

Research goals this class touches
Cognitive / focusSleep

FAQ

Which cognitive neuropeptides has the strongest evidence?

Semax currently grades highest in this class (D-tier) on published evidence — which reflects evidence maturity, not a recommendation.

Are any cognitive neuropeptides FDA-approved?

No members of this class are FDA-approved; they are investigational or research-only.

How do compounds in this class differ?

Proposed neuromodulatory and neurotrophic mechanisms. Human evidence varies and is often limited; nootropic claims frequently outrun the data. Within the class, members differ widely in evidence maturity, approval status, and safety — the tiers and evidence stages above show how.

Keep reading
Mechanisms

The pathways these classes act through.

The peptide database

Every compound, filterable by class.

Peptides 101

Background on how peptide classes differ.

The tier board

Compare classes by published evidence.

Research reference only. Not medical advice. Compounds in a class can differ greatly in evidence, approval status, and safety.

The all-in-one peptide app

Stop reading, start tracking.

PepCue logs your doses, runs the vial math, counts your vials, and keeps the whole protocol in one place. It replaces the spreadsheet, the calculator, and the sticky notes.

  • Dose logging
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