Sleep peptides
Peptides discussed for sleep and calm; evidence is limited and early.
S is approval-grade evidence; F is documented harm or near-zero human data. Each bar is how many peptides on this page land in that tier — a fast read on how much of this category sits in approval-grade evidence versus thin or vendor-driven claims.
The category at a glance
Every compound here ranked S–F by its weighted evidence score — strongest human / approval-grade evidence at the top, thin or vendor-driven claims at the bottom. Tap any row for the evidence read. Popularity never raises a tier.
Receipts, not vendor theater. Every tier here is computed from published evidence and regulatory status — not vendor marketing or influencer claims. See how we score.
DselankEarly human evidenceMedium overstatementResearch-use-only41/ 100
A synthetic heptapeptide derived from the immune peptide tuftsin, developed in Russia as an anxiolytic with reported nootropic effects. Human evidence is limited and largely confined to Russian-language studies (e.g. comparison with a benzodiazepine in anxiety); not approved in the US or EU.
Tier read: early human evidence · medium overstatement risk · low search interest · Early human. Why not F: supported by its overall evidence profile. Why not C: held back by human evidence, safety clarity, regulatory clarity, practical relevance.
Read the full selank profile →FdsipEarly human evidenceMedium overstatementResearch-use-only22/ 100
Delta sleep-inducing peptide, a nonapeptide proposed to promote slow-wave sleep. Across the literature, human sleep results have been inconsistent; it never reached established clinical use and its physiological role remains unresolved.
Tier read: early human evidence · medium overstatement risk · low search interest · Anecdote. Why not D: held back by human evidence, preclinical depth, mechanism confidence, safety clarity, regulatory clarity, practical relevance.
Read the full dsip profile →Sleep peptides are a small, early category. DSIP (delta sleep-inducing peptide) is the headline name, but its evidence is old and inconsistent — it is not an established sleep treatment.
What the evidence actually supports
DSIP is an endogenous neuropeptide historically linked to delta-wave sleep and stress modulation; the supporting human work is limited and dated. Selank is sometimes discussed for calm/anxiety rather than sleep per se.
Where the hype outruns the data
Framing any of these as a proven sleep treatment overstates the evidence. They don't replace sleep hygiene or medical evaluation of a sleep problem.
FAQ
Does DSIP work for sleep?
The evidence is old and inconsistent; DSIP is not an established sleep treatment.
Is this medical advice?
No — research reference only.
What should I read first?
Start with the best-supported options on this page, then check each compound's evidence stage and safety notes.
Research reference only. Not medical advice, dosing, or a recommendation to use any compound. “Worth watching” ≠ proven or safe.