Journal articleHuman

The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI

Nature communications, 2025 Jul 1. Bourgeois B, Spreitzer E, Platero-Rochart D and 7 others.

Study type

Journal article

Subjects

Human participants (PubMed MeSH: Humans)

Journal

Nature communications

Published

2025 Jul 1

PubMed

PMID 40593617 ↗

DOI

10.1038/s41467-025-60844-9 ↗

Full text

Free on PubMed Central (PMC12216184) ↗

Where PepCue cites this

This paper is part of the evidence base behind this profile. Citing a study is not an endorsement of the compound: papers that found no effect are indexed the same way.

FOXO4-DRI →

Indexed under

MeSH terms assigned by the National Library of Medicine.

Tumor Suppressor Protein p53HumansForkhead Transcription FactorsCell Cycle ProteinsCellular SenescenceProtein BindingProtein DomainsPhosphorylationTranscription FactorsTranscriptional ActivationModels, Molecular

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Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes

Journal article · 2017

Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

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