ReviewHuman

Relaxin agonists under preclinical and early clinical investigation for the treatment of heart failure

Expert opinion on investigational drugs, 2024 Dec. Ajay A, Biju P, Ajay H and 3 others.

Study type
Review
Subjects
Human participants (PubMed MeSH: Humans)
Journal
Expert opinion on investigational drugs
Published
2024 Dec
PubMed
PMID 39641766 ↗
DOI
10.1080/13543784.2024.2438663 ↗

Where PepCue cites this

This paper is part of the evidence base behind this profile. Citing a study is not an endorsement of the compound: papers that found no effect are indexed the same way.

B7-33 →

Indexed under

MeSH terms assigned by the National Library of Medicine.

HumansHeart FailureRelaxinAnimalsAcute DiseaseBiomarkersDrug Development

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End-organ protective effect of serelaxin in patients hospitalized for heart failure: Results of the biomarker substudy of Relaxin in Acute Heart Failure-2 (RELAX-AHF-2)
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The single-chain relaxin mimetic, B7-33, maintains the cardioprotective effects of relaxin and more rapidly reduces left ventricular fibrosis compared to perindopril in an experimental model of cardiomyopathy
Journal article · 2016
A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1

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Compounds