Titration.

Gradually adjusting a dose to a target.

Titration is the clinical practice of starting at a low amount and adjusting stepwise toward a target, allowing time at each step before deciding whether to move again. The reasons it exists are physiological. Many systems adapt to a compound over days or weeks, so tolerability at a given level often improves with continued exposure, and side effects that would be intolerable if encountered immediately can be manageable when approached gradually. Titration also allows the smallest effective amount to be identified for an individual rather than assuming everyone needs the same, and it gives time to detect problems early while exposure is still low. In the GLP-1 receptor agonist class this is a defining feature of how the drugs are used, precisely because the gastrointestinal effects that come with these compounds are strongly influenced by how quickly the level is raised. The concept is included in this glossary only so the term is comprehensible in the surrounding literature. This site does not provide dosing schedules, starting amounts, target amounts, or escalation intervals for any compound, and those decisions belong with a qualified prescriber working from the approved product information for the specific drug involved.