Orforglipron alternatives.

10 compounds compared to Orforglipron, ranked by published evidence tier and regulatory status, not by what's marketed hardest.

What you're comparing against
Orforglipron
FDA-approved

Orforglipron (brand: Foundayo, development code LY3502970) is a once-daily, orally administered GLP-1 receptor agonist developed by Eli Lilly.

Ranked by evidence · strongest first
  1. 01
    Semaglutide
    S tierFDA-approved
    Ozempic · Wegovy

    Same category: metabolic & glp-1. FDA-approved.

  2. 02
    Liraglutide
    S tierFDA-approved
    Victoza · Saxenda

    Same category: metabolic & glp-1. FDA-approved.

  3. 03
    Tirzepatide
    S tierFDA-approved
    Mounjaro · Zepbound

    Same category: metabolic & glp-1. FDA-approved.

  4. 04
    Survodutide
    B tierIn human trials
    BI 456906

    Same category: metabolic & glp-1. In human trials.

  5. 05
    Mazdutide
    B tierIn human trials
    IBI362 · LY3305677

    Same category: metabolic & glp-1. In human trials.

  6. 06
    Retatrutide
    B tierIn human trials
    triple agonist

    Same category: metabolic & glp-1. In human trials.

  7. 07
    Cagrilintide
    C tierIn human trials
    amylin analog

    Same category: metabolic & glp-1. In human trials.

  8. 08
    CagriSema
    C tierIn human trials
    cagrilintide + semaglutide

    Same category: metabolic & glp-1. In human trials.

  9. 09
    AOD-9604
    D tierResearch / preclinical

    Same category: metabolic & glp-1. Research / preclinical.

  10. 10
    HGH Fragment 176-191
    F tierResearch / preclinical
    hGH frag 176-191 · GH lipolytic fragment

    Same category: metabolic & glp-1. Research / preclinical.

How this list is built

An “alternative” here means a compound that shares Orforglipron's mechanism pathway or sits in the same category, not a marketing substitute. Each is ordered by PepCue's evidence tier (a weighted 0–100 score across human data, safety, replication and regulatory clarity), then by whether it's actually approved. This is a research reference, not medical or purchasing advice: an alternative sitting higher on evidence does not mean it's right, safe, or legal for any given use. Reviewed June 1, 2026.

Comparing options with your provider?

PepCue keeps every compound, dose and lab in one private, provider-ready timeline, whichever one you land on.

Educational and research reference only. Not medical advice, diagnosis, or dosing guidance. Flag an error on this page
Compounds