B7-33 alternatives.

5 compounds compared to B7-33, ranked by published evidence tier and regulatory status, not by what's marketed hardest.

Why people look for an alternative

B7-33 exists because native relaxin-2 is a two-chain, disulfide-linked hormone that is difficult and expensive to manufacture, and a single-chain 24-amino-acid mimetic is not. Its studied effects are anti-fibrotic, in cells and animals, across heart, kidney, lung, and vascular tissue. Anyone looking for an alternative has usually noticed the next line: it has never been tested in humans, has no approval, and is sold only as a research reagent labeled not for human consumption. There is no better-evidenced peptide acting through the relaxin receptor pathway. The compounds below overlap with B7-33 on tissue repair as a category, not on mechanism or on clinical proof.

What you're comparing against
B7-33
F tier · 24/100Research / preclinical

B7-33 is an experimental single-chain peptide derived from the B-chain of the human hormone relaxin-2 (H2 relaxin).

Ranked by evidence · strongest first
  1. 01
    Pentosan Polysulfate
    B tierFDA-approved
    Elmiron

    Same category: healing & recovery. FDA-approved.

  2. 02
    Larazotide
    C tierIn human trials
    AT-1001 · larazotide acetate

    Same category: healing & recovery. In human trials.

  3. 03
    Thymosin β-4
    D tierResearch / preclinical

    Same category: healing & recovery. Research / preclinical.

  4. 04
    BPC-157
    D tierResearch / preclinical
    body protection compound

    Same category: healing & recovery. Research / preclinical.

  5. 05
    TB-500
    F tierResearch / preclinical
    thymosin β4 fragment

    Same category: healing & recovery. Research / preclinical.

How this list is built

An “alternative” here means a compound that shares B7-33's mechanism pathway or sits in the same category, not a marketing substitute. Each is ordered by PepCue's evidence tier (a weighted 0–100 score across human data, safety, replication and regulatory clarity), then by whether it's actually approved. This is a research reference, not medical or purchasing advice: an alternative sitting higher on evidence does not mean it's right, safe, or legal for any given use. Reviewed June 1, 2026.

Comparing options with your provider?

PepCue keeps every compound, dose and lab in one private, provider-ready timeline, whichever one you land on.

Educational and research reference only. Not medical advice, diagnosis, or dosing guidance. Flag an error on this page
Compounds