AOD-9604 alternatives.
10 compounds compared to AOD-9604, ranked by published evidence tier and regulatory status, not by what's marketed hardest.
AOD-9604 was engineered at Monash to isolate growth hormone's fat-mobilizing region while leaving out its growth-promoting and IGF-1-raising actions. The alternatives search starts where that program ended: the obesity development effort was discontinued, it holds no approval for any therapeutic use, and the FDA has flagged peptide candidates of this type as raising significant safety questions in its review of substances nominated for pharmacy compounding. It is also prohibited in sport and tested for under the WADA framework. No GH-fragment approach reached approval for weight loss, so the approved alternatives in this space act on appetite hormones instead, which is a different mechanism rather than a refined one.
AOD-9604 ("Advanced Obesity Drug 9604") is a synthetic 16-amino-acid peptide corresponding to the C-terminal lipolytic region of human growth hormone (hGH), residues 177–191, with an added tyrosine at the N-terminus.
- 01HGH Fragment 176-191F tierResearch / preclinicalhGH frag 176-191 · GH lipolytic fragment
Acts through the adipose tissue and lipolysis signalling pathway, like AOD-9604. Research / preclinical.
- 02AdipotideF tierResearch / preclinicalFTPP
Acts through the adipose tissue and lipolysis signalling pathway, like AOD-9604. Research / preclinical.
- 035-Amino-1MQF tierResearch / preclinical
Acts through the adipose tissue and lipolysis signalling pathway, like AOD-9604. Research / preclinical.
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An “alternative” here means a compound that shares AOD-9604's mechanism pathway or sits in the same category, not a marketing substitute. Each is ordered by PepCue's evidence tier (a weighted 0–100 score across human data, safety, replication and regulatory clarity), then by whether it's actually approved. This is a research reference, not medical or purchasing advice: an alternative sitting higher on evidence does not mean it's right, safe, or legal for any given use. Reviewed June 1, 2026.
PepCue keeps every compound, dose and lab in one private, provider-ready timeline, whichever one you land on.