Mitochondrial & longevity peptides

Mitochondria-derived and longevity-associated research peptides. Among the most hype-prone and least clinically validated groups.

How this class works

Proposed roles include mitochondrial function and stress-response signalling. Evidence is predominantly preclinical or mechanistic; longevity claims are generally unproven in humans.

Best-supported in this class

SS 31 grades highest (C-tier) on current published evidence. This reflects evidence maturity — not a recommendation to use anything.

Compounds in this class

SS 31C
Early human
Best for: longevity / mitochondrial research
In progress
Mots CF
Animal
Best for: early longevity / mitochondrial research
In progress
HumaninF
Animal
Best for: early longevity / mitochondrial research
In progress
EpitalonF
Anecdote
Best for: early longevity / mitochondrial research
In progress
Foxo4 DRIF
Mechanism
Best for: early longevity / mitochondrial research
In progress
PinealonF
Anecdote
Best for: early longevity / mitochondrial research
In progress

Head-to-head: SS 31 vs Mots C

Research goals this class touches
Longevity / mitochondrial

FAQ

Which mitochondrial & longevity peptides has the strongest evidence?

SS 31 currently grades highest in this class (C-tier) on published evidence — which reflects evidence maturity, not a recommendation.

Are any mitochondrial & longevity peptides FDA-approved?

No members of this class are FDA-approved; they are investigational or research-only.

How do compounds in this class differ?

Proposed roles include mitochondrial function and stress-response signalling. Evidence is predominantly preclinical or mechanistic; longevity claims are generally unproven in humans. Within the class, members differ widely in evidence maturity, approval status, and safety — the tiers and evidence stages above show how.

Keep reading
Mechanisms

The pathways these classes act through.

The peptide database

Every compound, filterable by class.

Peptides 101

Background on how peptide classes differ.

The tier board

Compare classes by published evidence.

Research reference only. Not medical advice. Compounds in a class can differ greatly in evidence, approval status, and safety.

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