Melanocortin & sexual-health peptides

Peptides acting on melanocortin and reproductive-hormone pathways, including an approved agent for a specific indication.

How this class works

Mechanisms include melanocortin-receptor activation and effects on reproductive-hormone signalling and central pathways relevant to libido.

Best-supported in this class

Oxytocin grades highest (S-tier) on current published evidence; approved members: PT 141, Oxytocin. This reflects evidence maturity — not a recommendation to use anything.

Compounds in this class

OxytocinS
Approved use
Best for: approved libido / sexual health use
In progress
PT 141B
Approved use
Best for: approved libido / sexual health use
In progress
KisspeptinD
Early human
Best for: libido / sexual health research
In progress
Melanotan IID
Early human
Best for: early libido / sexual health research
In progress

Head-to-head: Oxytocin vs PT 141

Research goals this class touches
Libido / sexual health

FAQ

Which melanocortin & sexual-health peptides has the strongest evidence?

Oxytocin currently grades highest in this class (S-tier) on published evidence — which reflects evidence maturity, not a recommendation.

Are any melanocortin & sexual-health peptides FDA-approved?

Yes — PT 141, Oxytocin are FDA-approved for specific indications. Others in the class are investigational or research-only.

How do compounds in this class differ?

Mechanisms include melanocortin-receptor activation and effects on reproductive-hormone signalling and central pathways relevant to libido. Within the class, members differ widely in evidence maturity, approval status, and safety — the tiers and evidence stages above show how.

Keep reading
Mechanisms

The pathways these classes act through.

The peptide database

Every compound, filterable by class.

Peptides 101

Background on how peptide classes differ.

The tier board

Compare classes by published evidence.

Research reference only. Not medical advice. Compounds in a class can differ greatly in evidence, approval status, and safety.

The all-in-one peptide app

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PepCue logs your doses, runs the vial math, counts your vials, and keeps the whole protocol in one place. It replaces the spreadsheet, the calculator, and the sticky notes.

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