IGF axis & growth-factor peptides

Growth-hormone, IGF-axis, and related growth-factor peptides and fragments.

How this class works

Effects centre on the growth-hormone/IGF-1 signalling axis and related growth-factor pathways. Approval status and evidence differ widely across the group.

Best-supported in this class

Human Growth Hormone grades highest (S-tier) on current published evidence; approved members: Human Growth Hormone. This reflects evidence maturity — not a recommendation to use anything.

Compounds in this class

Human Growth HormoneS
Approved use
Best for: approved growth hormone axis use
In progress
AOD 9604D
Early human
Best for: early weight loss research
In progress
IGF 1 LR3F
Animal
Best for: early growth hormone axis research
In progress
HGH Fragment 176 191F
Animal
In progress
Follistatin 344F
Animal
Best for: early sports / performance (caution) research
In progress
PEG MGFF
Anecdote
Best for: early sports / performance (caution) research
In progress

Head-to-head: Human Growth Hormone vs AOD 9604

Research goals this class touches
Growth hormone axisWeight lossSports / performance (caution)

FAQ

Which igf axis & growth-factor peptides has the strongest evidence?

Human Growth Hormone currently grades highest in this class (S-tier) on published evidence — which reflects evidence maturity, not a recommendation.

Are any igf axis & growth-factor peptides FDA-approved?

Yes — Human Growth Hormone is FDA-approved for specific indications. Others in the class are investigational or research-only.

How do compounds in this class differ?

Effects centre on the growth-hormone/IGF-1 signalling axis and related growth-factor pathways. Approval status and evidence differ widely across the group. Within the class, members differ widely in evidence maturity, approval status, and safety — the tiers and evidence stages above show how.

Keep reading
Mechanisms

The pathways these classes act through.

The peptide database

Every compound, filterable by class.

Peptides 101

Background on how peptide classes differ.

The tier board

Compare classes by published evidence.

Research reference only. Not medical advice. Compounds in a class can differ greatly in evidence, approval status, and safety.

The all-in-one peptide app

Stop reading, start tracking.

PepCue logs your doses, runs the vial math, counts your vials, and keeps the whole protocol in one place. It replaces the spreadsheet, the calculator, and the sticky notes.

  • Dose logging
  • Reconstitution math
  • Smart reminders
  • Vial & cost tracking
iPhone · free to start