{
  "name": "PepCue peptide evidence tiers",
  "url": "https://www.pepcue.app/tier",
  "methodology": "https://www.pepcue.app/methodology",
  "publisher": "PepCue",
  "gradesReviewed": "2026-06-01",
  "regulatoryStatusUpdated": "2026-09-23",
  "whatATierMeans": "A tier grades the strength of published evidence for a compound, not whether it works for any individual or is safe to use. It is not medical advice and not a recommendation to use anything.",
  "scale": {
    "S": "90-100",
    "A": "78-89",
    "B": "65-77",
    "C": "50-64",
    "D": "35-49",
    "F": "0-34"
  },
  "ungradedMeans": "tier: null means the compound has not been scored yet. No grade is guessed.",
  "suggestedCitation": "PepCue. Peptide evidence tiers. https://www.pepcue.app/tier. Grades reviewed 2026-06-01.",
  "compounds": [
    {
      "slug": "semaglutide",
      "name": "Semaglutide",
      "aka": "Ozempic · Wegovy",
      "category": "Metabolic & GLP-1",
      "regulatoryStatus": "FDA-approved",
      "tier": "S",
      "score": 95,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/semaglutide"
    },
    {
      "slug": "liraglutide",
      "name": "Liraglutide",
      "aka": "Victoza · Saxenda",
      "category": "Metabolic & GLP-1",
      "regulatoryStatus": "FDA-approved",
      "tier": "S",
      "score": 93,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/liraglutide"
    },
    {
      "slug": "tirzepatide",
      "name": "Tirzepatide",
      "aka": "Mounjaro · Zepbound",
      "category": "Metabolic & GLP-1",
      "regulatoryStatus": "FDA-approved",
      "tier": "S",
      "score": 92,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/tirzepatide"
    },
    {
      "slug": "hcg",
      "name": "HCG",
      "aka": "human chorionic gonadotropin · Pregnyl",
      "category": "Sexual health",
      "regulatoryStatus": "FDA-approved",
      "tier": "S",
      "score": 90,
      "citedSources": 5,
      "url": "https://www.pepcue.app/p/hcg"
    },
    {
      "slug": "human-growth-hormone",
      "name": "Human Growth Hormone",
      "aka": "HGH · somatropin",
      "category": "Growth hormone",
      "regulatoryStatus": "FDA-approved",
      "tier": "S",
      "score": 90,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/human-growth-hormone"
    },
    {
      "slug": "orforglipron",
      "name": "Orforglipron",
      "aka": "Foundayo, LY3502970",
      "category": "Metabolic & GLP-1",
      "regulatoryStatus": "FDA-approved",
      "tier": "S",
      "score": 90,
      "citedSources": 8,
      "url": "https://www.pepcue.app/p/orforglipron"
    },
    {
      "slug": "oxytocin",
      "name": "Oxytocin",
      "aka": "Pitocin",
      "category": "Sexual health",
      "regulatoryStatus": "FDA-approved",
      "tier": "S",
      "score": 90,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/oxytocin"
    },
    {
      "slug": "afamelanotide",
      "name": "Afamelanotide",
      "aka": "Melanotan I · Scenesse",
      "category": "Skin & cosmetic",
      "regulatoryStatus": "FDA-approved",
      "tier": "A",
      "score": 88,
      "citedSources": 7,
      "url": "https://www.pepcue.app/p/afamelanotide"
    },
    {
      "slug": "tesamorelin",
      "name": "Tesamorelin",
      "aka": "Egrifta",
      "category": "Growth hormone",
      "regulatoryStatus": "FDA-approved",
      "tier": "A",
      "score": 87,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/tesamorelin"
    },
    {
      "slug": "gonadorelin",
      "name": "Gonadorelin",
      "aka": "GnRH · Factrel",
      "category": "Sexual health",
      "regulatoryStatus": "FDA-approved",
      "tier": "A",
      "score": 80,
      "citedSources": 6,
      "url": "https://www.pepcue.app/p/gonadorelin"
    },
    {
      "slug": "pt-141",
      "name": "PT-141",
      "aka": "bremelanotide · Vyleesi",
      "category": "Sexual health",
      "regulatoryStatus": "FDA-approved",
      "tier": "B",
      "score": 76,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/pt-141"
    },
    {
      "slug": "pentosan-polysulfate",
      "name": "Pentosan Polysulfate",
      "aka": "Elmiron",
      "category": "Healing & recovery",
      "regulatoryStatus": "FDA-approved",
      "tier": "B",
      "score": 73,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/pentosan-polysulfate"
    },
    {
      "slug": "survodutide",
      "name": "Survodutide",
      "aka": "BI 456906",
      "category": "Metabolic & GLP-1",
      "regulatoryStatus": "Investigational",
      "tier": "B",
      "score": 70,
      "citedSources": 6,
      "url": "https://www.pepcue.app/p/survodutide"
    },
    {
      "slug": "ss-31",
      "name": "SS-31",
      "aka": "elamipretide, Forzinity",
      "category": "Longevity",
      "regulatoryStatus": "FDA-approved",
      "tier": "B",
      "score": 69,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/ss-31"
    },
    {
      "slug": "mazdutide",
      "name": "Mazdutide",
      "aka": "IBI362 · LY3305677",
      "category": "Metabolic & GLP-1",
      "regulatoryStatus": "Investigational",
      "tier": "B",
      "score": 68,
      "citedSources": 6,
      "url": "https://www.pepcue.app/p/mazdutide"
    },
    {
      "slug": "retatrutide",
      "name": "Retatrutide",
      "aka": "triple agonist",
      "category": "Metabolic & GLP-1",
      "regulatoryStatus": "Investigational",
      "tier": "B",
      "score": 68,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/retatrutide"
    },
    {
      "slug": "larazotide",
      "name": "Larazotide",
      "aka": "AT-1001 · larazotide acetate",
      "category": "Healing & recovery",
      "regulatoryStatus": "Investigational",
      "tier": "C",
      "score": 63,
      "citedSources": 5,
      "url": "https://www.pepcue.app/p/larazotide"
    },
    {
      "slug": "cerebrolysin",
      "name": "Cerebrolysin",
      "aka": "porcine brain peptide preparation",
      "category": "Cognition & mood",
      "regulatoryStatus": "Investigational",
      "tier": "C",
      "score": 59,
      "citedSources": 5,
      "url": "https://www.pepcue.app/p/cerebrolysin"
    },
    {
      "slug": "sermorelin",
      "name": "Sermorelin",
      "aka": null,
      "category": "Growth hormone",
      "regulatoryStatus": "Research-use-only",
      "tier": "C",
      "score": 58,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/sermorelin"
    },
    {
      "slug": "thymosin-alpha-1",
      "name": "Thymosin α-1",
      "aka": "Zadaxin",
      "category": "Immune & inflammation",
      "regulatoryStatus": "Investigational",
      "tier": "C",
      "score": 56,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/thymosin-alpha-1"
    },
    {
      "slug": "cagrilintide",
      "name": "Cagrilintide",
      "aka": "amylin analog",
      "category": "Metabolic & GLP-1",
      "regulatoryStatus": "Investigational",
      "tier": "C",
      "score": 53,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/cagrilintide"
    },
    {
      "slug": "cagrisema",
      "name": "CagriSema",
      "aka": "cagrilintide + semaglutide",
      "category": "Metabolic & GLP-1",
      "regulatoryStatus": "Investigational",
      "tier": "C",
      "score": 53,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/cagrisema"
    },
    {
      "slug": "vip",
      "name": "VIP",
      "aka": "vasoactive intestinal peptide",
      "category": "Immune & inflammation",
      "regulatoryStatus": "Research-use-only",
      "tier": "C",
      "score": 50,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/vip"
    },
    {
      "slug": "ace-031",
      "name": "ACE-031",
      "aka": "ramatercept · ActRIIB-Fc",
      "category": "Growth hormone",
      "regulatoryStatus": "Investigational",
      "tier": "D",
      "score": 49,
      "citedSources": 5,
      "url": "https://www.pepcue.app/p/ace-031"
    },
    {
      "slug": "kisspeptin",
      "name": "Kisspeptin",
      "aka": null,
      "category": "Sexual health",
      "regulatoryStatus": "Research-use-only",
      "tier": "D",
      "score": 47,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/kisspeptin"
    },
    {
      "slug": "ghk-cu",
      "name": "GHK-Cu",
      "aka": "copper peptide",
      "category": "Skin & cosmetic",
      "regulatoryStatus": "Research-use-only",
      "tier": "D",
      "score": 45,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/ghk-cu"
    },
    {
      "slug": "glutathione",
      "name": "Glutathione",
      "aka": "GSH · reduced glutathione",
      "category": "Longevity",
      "regulatoryStatus": "Research-use-only",
      "tier": "D",
      "score": 45,
      "citedSources": 7,
      "url": "https://www.pepcue.app/p/glutathione"
    },
    {
      "slug": "aod-9604",
      "name": "AOD-9604",
      "aka": null,
      "category": "Metabolic & GLP-1",
      "regulatoryStatus": "Research-use-only",
      "tier": "D",
      "score": 41,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/aod-9604"
    },
    {
      "slug": "selank",
      "name": "Selank",
      "aka": null,
      "category": "Cognition & mood",
      "regulatoryStatus": "Research-use-only",
      "tier": "D",
      "score": 41,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/selank"
    },
    {
      "slug": "semax",
      "name": "Semax",
      "aka": null,
      "category": "Cognition & mood",
      "regulatoryStatus": "Research-use-only",
      "tier": "D",
      "score": 41,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/semax"
    },
    {
      "slug": "thymosin-beta-4",
      "name": "Thymosin β-4",
      "aka": null,
      "category": "Healing & recovery",
      "regulatoryStatus": "Research-use-only",
      "tier": "D",
      "score": 40,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/thymosin-beta-4"
    },
    {
      "slug": "argireline",
      "name": "Argireline",
      "aka": "acetyl hexapeptide-8",
      "category": "Skin & cosmetic",
      "regulatoryStatus": "Research-use-only",
      "tier": "D",
      "score": 39,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/argireline"
    },
    {
      "slug": "bpc-157",
      "name": "BPC-157",
      "aka": "body protection compound",
      "category": "Healing & recovery",
      "regulatoryStatus": "Research-use-only",
      "tier": "D",
      "score": 39,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/bpc-157"
    },
    {
      "slug": "thymalin",
      "name": "Thymalin",
      "aka": "thymus peptide extract",
      "category": "Immune & inflammation",
      "regulatoryStatus": "Investigational",
      "tier": "D",
      "score": 39,
      "citedSources": 6,
      "url": "https://www.pepcue.app/p/thymalin"
    },
    {
      "slug": "ghrp-1",
      "name": "GHRP-1",
      "aka": "growth hormone-releasing peptide-1",
      "category": "Growth hormone",
      "regulatoryStatus": "Research-use-only",
      "tier": "D",
      "score": 38,
      "citedSources": 5,
      "url": "https://www.pepcue.app/p/ghrp-1"
    },
    {
      "slug": "ghrp-2",
      "name": "GHRP-2",
      "aka": null,
      "category": "Growth hormone",
      "regulatoryStatus": "Research-use-only",
      "tier": "D",
      "score": 38,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/ghrp-2"
    },
    {
      "slug": "ghrp-6",
      "name": "GHRP-6",
      "aka": null,
      "category": "Growth hormone",
      "regulatoryStatus": "Research-use-only",
      "tier": "D",
      "score": 38,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/ghrp-6"
    },
    {
      "slug": "hexarelin",
      "name": "Hexarelin",
      "aka": null,
      "category": "Growth hormone",
      "regulatoryStatus": "Research-use-only",
      "tier": "D",
      "score": 38,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/hexarelin"
    },
    {
      "slug": "melanotan-ii",
      "name": "Melanotan II",
      "aka": null,
      "category": "Skin & cosmetic",
      "regulatoryStatus": "Research-use-only",
      "tier": "D",
      "score": 38,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/melanotan-ii"
    },
    {
      "slug": "matrixyl",
      "name": "Matrixyl",
      "aka": "palmitoyl pentapeptide",
      "category": "Skin & cosmetic",
      "regulatoryStatus": "Research-use-only",
      "tier": "D",
      "score": 37,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/matrixyl"
    },
    {
      "slug": "cortexin",
      "name": "Cortexin",
      "aka": "cattle brain polypeptides",
      "category": "Cognition & mood",
      "regulatoryStatus": "Investigational",
      "tier": "D",
      "score": 35,
      "citedSources": 5,
      "url": "https://www.pepcue.app/p/cortexin"
    },
    {
      "slug": "snap-8",
      "name": "SNAP-8",
      "aka": "acetyl octapeptide-3",
      "category": "Skin & cosmetic",
      "regulatoryStatus": "Research-use-only",
      "tier": "D",
      "score": 35,
      "citedSources": 5,
      "url": "https://www.pepcue.app/p/snap-8"
    },
    {
      "slug": "ll-37",
      "name": "LL-37",
      "aka": null,
      "category": "Immune & inflammation",
      "regulatoryStatus": "Research-use-only",
      "tier": "F",
      "score": 34,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/ll-37"
    },
    {
      "slug": "cjc-1295",
      "name": "CJC-1295",
      "aka": null,
      "category": "Growth hormone",
      "regulatoryStatus": "Research-use-only",
      "tier": "F",
      "score": 33,
      "citedSources": 3,
      "url": "https://www.pepcue.app/p/cjc-1295"
    },
    {
      "slug": "igf-1-lr3",
      "name": "IGF-1 LR3",
      "aka": null,
      "category": "Growth hormone",
      "regulatoryStatus": "Research-use-only",
      "tier": "F",
      "score": 33,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/igf-1-lr3"
    },
    {
      "slug": "ipamorelin",
      "name": "Ipamorelin",
      "aka": null,
      "category": "Growth hormone",
      "regulatoryStatus": "Research-use-only",
      "tier": "F",
      "score": 33,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/ipamorelin"
    },
    {
      "slug": "hgh-fragment-176-191",
      "name": "HGH Fragment 176-191",
      "aka": "hGH frag 176-191 · GH lipolytic fragment",
      "category": "Metabolic & GLP-1",
      "regulatoryStatus": "Research-use-only",
      "tier": "F",
      "score": 30,
      "citedSources": 5,
      "url": "https://www.pepcue.app/p/hgh-fragment-176-191"
    },
    {
      "slug": "mots-c",
      "name": "MOTS-c",
      "aka": null,
      "category": "Longevity",
      "regulatoryStatus": "Research-use-only",
      "tier": "F",
      "score": 30,
      "citedSources": 2,
      "url": "https://www.pepcue.app/p/mots-c"
    },
    {
      "slug": "tb-500",
      "name": "TB-500",
      "aka": "thymosin β4 fragment",
      "category": "Healing & recovery",
      "regulatoryStatus": "Research-use-only",
      "tier": "F",
      "score": 30,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/tb-500"
    },
    {
      "slug": "cjc-1295-dac",
      "name": "CJC-1295 DAC",
      "aka": null,
      "category": "Growth hormone",
      "regulatoryStatus": "Research-use-only",
      "tier": "F",
      "score": 29,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/cjc-1295-dac"
    },
    {
      "slug": "mod-grf-1-29",
      "name": "Mod-GRF (1-29)",
      "aka": "CJC-1295 no-DAC",
      "category": "Growth hormone",
      "regulatoryStatus": "Research-use-only",
      "tier": "F",
      "score": 29,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/mod-grf-1-29"
    },
    {
      "slug": "n-acetyl-semax-amidate",
      "name": "N-Acetyl Semax Amidate",
      "aka": null,
      "category": "Cognition & mood",
      "regulatoryStatus": "Research-use-only",
      "tier": "F",
      "score": 29,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/n-acetyl-semax-amidate"
    },
    {
      "slug": "follistatin-344",
      "name": "Follistatin-344",
      "aka": null,
      "category": "Growth hormone",
      "regulatoryStatus": "Research-use-only",
      "tier": "F",
      "score": 28,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/follistatin-344"
    },
    {
      "slug": "humanin",
      "name": "Humanin",
      "aka": null,
      "category": "Longevity",
      "regulatoryStatus": "Research-use-only",
      "tier": "F",
      "score": 28,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/humanin"
    },
    {
      "slug": "kpv",
      "name": "KPV",
      "aka": null,
      "category": "Immune & inflammation",
      "regulatoryStatus": "Research-use-only",
      "tier": "F",
      "score": 28,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/kpv"
    },
    {
      "slug": "b7-33",
      "name": "B7-33",
      "aka": "single-chain relaxin analog",
      "category": "Healing & recovery",
      "regulatoryStatus": "Research-use-only",
      "tier": "F",
      "score": 24,
      "citedSources": 5,
      "url": "https://www.pepcue.app/p/b7-33"
    },
    {
      "slug": "pe-22-28",
      "name": "PE-22-28",
      "aka": "spadin analog",
      "category": "Cognition & mood",
      "regulatoryStatus": "Research-use-only",
      "tier": "F",
      "score": 24,
      "citedSources": 5,
      "url": "https://www.pepcue.app/p/pe-22-28"
    },
    {
      "slug": "dsip",
      "name": "DSIP",
      "aka": "delta sleep-inducing peptide",
      "category": "Cognition & mood",
      "regulatoryStatus": "Research-use-only",
      "tier": "F",
      "score": 22,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/dsip"
    },
    {
      "slug": "epitalon",
      "name": "Epitalon",
      "aka": null,
      "category": "Longevity",
      "regulatoryStatus": "Research-use-only",
      "tier": "F",
      "score": 22,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/epitalon"
    },
    {
      "slug": "p21",
      "name": "P21",
      "aka": "P021 · CNTF-derived peptide mimetic",
      "category": "Cognition & mood",
      "regulatoryStatus": "Research-use-only",
      "tier": "F",
      "score": 22,
      "citedSources": 5,
      "url": "https://www.pepcue.app/p/p21"
    },
    {
      "slug": "adipotide",
      "name": "Adipotide",
      "aka": "FTPP",
      "category": "Metabolic & GLP-1",
      "regulatoryStatus": "Research-use-only",
      "tier": "F",
      "score": 21,
      "citedSources": 5,
      "url": "https://www.pepcue.app/p/adipotide"
    },
    {
      "slug": "5-amino-1mq",
      "name": "5-Amino-1MQ",
      "aka": null,
      "category": "Longevity",
      "regulatoryStatus": "Research-use-only",
      "tier": "F",
      "score": 15,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/5-amino-1mq"
    },
    {
      "slug": "dihexa",
      "name": "Dihexa",
      "aka": null,
      "category": "Cognition & mood",
      "regulatoryStatus": "Research-use-only",
      "tier": "F",
      "score": 15,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/dihexa"
    },
    {
      "slug": "foxo4-dri",
      "name": "FOXO4-DRI",
      "aka": null,
      "category": "Longevity",
      "regulatoryStatus": "Research-use-only",
      "tier": "F",
      "score": 15,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/foxo4-dri"
    },
    {
      "slug": "mgf",
      "name": "MGF",
      "aka": "mechano growth factor · IGF-1Ec",
      "category": "Growth hormone",
      "regulatoryStatus": "Research-use-only",
      "tier": "F",
      "score": 15,
      "citedSources": 5,
      "url": "https://www.pepcue.app/p/mgf"
    },
    {
      "slug": "vilon",
      "name": "Vilon",
      "aka": "Lys-Glu dipeptide",
      "category": "Longevity",
      "regulatoryStatus": "Research-use-only",
      "tier": "F",
      "score": 15,
      "citedSources": 6,
      "url": "https://www.pepcue.app/p/vilon"
    },
    {
      "slug": "peg-mgf",
      "name": "PEG-MGF",
      "aka": null,
      "category": "Growth hormone",
      "regulatoryStatus": "Research-use-only",
      "tier": "F",
      "score": 12,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/peg-mgf"
    },
    {
      "slug": "pinealon",
      "name": "Pinealon",
      "aka": null,
      "category": "Cognition & mood",
      "regulatoryStatus": "Research-use-only",
      "tier": "F",
      "score": 12,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/pinealon"
    },
    {
      "slug": "ptd-dbm",
      "name": "PTD-DBM",
      "aka": null,
      "category": "Skin & cosmetic",
      "regulatoryStatus": "Research-use-only",
      "tier": "F",
      "score": 12,
      "citedSources": 4,
      "url": "https://www.pepcue.app/p/ptd-dbm"
    }
  ]
}